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目的观察川芎嗪注射液联合缬沙坦治疗糖尿病肾病对尿蛋白素、血肌酐、血压及血溏的效果。方法均控制低盐饮食,降糖药物和胰岛素治疗的基础上口服缬沙坦胶囊80mg,每日一次口服,川芎嗪注射液120mg,每天静脉注射,四周为一疗程。结果 24h的蛋白尿定量、血肌酐及血压等情况均有明显下降,P<0.05为差别有显著性。结论川芎嗪注射液联合缬沙坦对DN患者能明显起到降低蛋白尿、血肌酐,延缓肾衰的进展,保护肾功能之有效方法。
Objective To observe the effect of ligustrazine injection combined with valsartan on urinary albumin, serum creatinine, blood pressure and blood stasis in patients with diabetic nephropathy. Methods Both low-salt diet, hypoglycemic drugs and insulin therapy based on oral valsartan capsules 80mg, once daily oral, ligustrazine injection 120mg, daily intravenous injection, four weeks for a course of treatment. Results 24h proteinuria quantitative, serum creatinine and blood pressure were significantly decreased, P <0.05 for the difference was significant. Conclusion Ligustrazine injection combined with valsartan can obviously reduce the proteinuria, serum creatinine, delay the progression of renal failure and protect renal function effectively.