系统性红斑狼疮是一种累及多系统的自身免疫性疾病 ,以自身抗体的产生和多器官功能受损为主要特征。近年来的研究表明 ,狼疮的发生与细胞凋亡紊乱密切相关。关于两者之间关系的研究最近又取得了进一步的进展。本文主要从系统性红斑狼疮存在细胞凋亡紊乱、凋亡物质的清除障碍、凋亡过程中自身抗原被修饰这三方面阐述细胞凋亡在其发病中的意义 Systemic lupus erythematosus is a multi-systemic autoimmune disease that is characterized by autoantibodies and impaired multiple organ function. Recent studies have shown that the occurrence of lupus and apoptosis are closely related to the disorder. Research on the relationship between the two has made further progress recently. This article mainly from the existence of systemic lupus erythematosus apoptosis disorders, removal of obstacles to the removal of substances, the process of apoptosis in the self-modified antigen these three aspects of the significance of apoptosis in its pathogenesis