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为探讨异种移植免疫耐受的可能性，以豚鼠一大鼠异位心脏移植超急排模型，在CVF（30U／kg）及环磷酸胺（CyP）覆盖下将供者特异性血管内皮细胞以4．0X106／只经受者门静脉输注，2周后行颈部心脏移植使移植供心存活时间获得延长（44．8～64．2min），同时血管内皮细胞溶解率下降。环磷酰胺及脾切除有一定延长移植物存活的作用（25．9～43．3min，30～47．2min），而非特异性血管内皮细胞无此作用。提示经门静脉输注供者特异性豚鼠血管内皮细胞可诱导大鼠产生一定程度的免疫耐受，这种耐受的产生机制尚需进一步研究。
To investigate the possibility of tolerance to xenotransplantation, a rat model of ectopic heart transplantation in guinea pigs was established. The donor-specific vascular endothelial cells were treated with CVF (30 U / kg) and cyclophosphamide (CyP) 4.0X106 / only by portal vein infusion, 2 weeks after cervical heart transplantation to donor heart survival time was extended (44.8 ~ 64.2min), while vascular endothelial cell lysis rate decreased. Cyclophosphamide and splenectomy have the effect of prolonging graft survival (25.9 ~ 43.3min, 30 ~ 47.2min), while non-specific vascular endothelial cells have no such effect. It is suggested that transfusion of donor-specific guinea pig vascular endothelial cells by portal vein can induce some degree of immune tolerance in rats. The mechanism of this tolerance needs further study.