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目的:了解青海省成人大骨节病(KBD)患者血清新碟呤(NPT)水平变化。方法:2018年7月在青海省海南藏族自治州兴海、贵德县KBD病区,依据《大骨节病诊断》(WS/T 207-2010),选取确诊的20岁以上成人KBD患者及健康人群分别作为KBD组和病区内对照组;同时,在生产、生活方式相似的非病区循化县选取20岁以上健康人群作为病区外对照组。采集3组人群空腹肘静脉血,采用酶联免疫吸附试验(ELISA)法检测血清NPT水平。结果:共调查272人,其中KBD组104人(男性50人、女性54人),年龄为(47.61 ± 12.72)岁;病区内对照组95人(男性35人、女性60人),年龄为(48.28 ± 14.87)岁;病区外对照组73人(男性35人、女性38人),年龄为(51.88 ± 13.93)岁。3组间性别构成、年龄比较,差异均无统计学意义(χn 2 = 3.135,n F = 2.236,n P均> 0.05)。KBD、病区内对照、病区外对照组血清NPT水平分别为(504.35 ± 413.92)、(417.34 ± 109.90)、(397.49 ± 118.07)ng/L,组间比较差异有统计学意义(n F = 4.129,n P 0.05). The serum NPT levels of KBD, internal control, and external control groups were (504.35 ± 413.92), (417.34 ± 109.90) and (397.49 ± 118.07) ng/L, respectively, and the difference among the 3 groups was statistically significant ( n F = 4.129, n P < 0.05). Among them, the serum NPT level of KBD group was significantly higher than that of internal control group and external control group ( n P 0.05).n Conclusion:The serum NPT level of adult KBD patients in Qinghai Province is elevated.