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为研究胎脑黑质脑内移植对帕金森氏病大鼠纹状体内神经肽Ｙ及多巴胺Ｄ２型受体ｍＲＮＡ表达的影响，本文采用核酸斑点杂交方法对胎脑黑质脑内移植前后的帕金森氏病大鼠纹状体内神经肽Ｙ及多巴胺Ｄ２型受体ｍＲＮＡ含量进行了连续定量地观察，研究发现胎脑黑质移植物不仅能纠正帕金森氏病大鼠的行为异常，而且还能彻底反转帕金森氏病大鼠纹状体内因去神经支配造成的神经肽Ｙ及多巴胺Ｄ２受体ｍＲＮＡ过度表达，研究结果提示胎脑黑质移植物对宿主纹状体形成的神经再支配可能是促使这两种物质基因表达正常化的主要原因。
In order to study the effect of fetal brain substantia nigra transplantation on neuropeptide Y and dopamine D2 receptor mRNA expression in striatum of Parkinson’s disease rats, we used dot blot hybridization The neuropeptide Y and dopamine D2 receptor mRNA levels in striatum of rats with Parkinson’s disease were observed quantitatively and continuously. It was found that fetus substantia nigra grafts could not only correct the behavioral abnormalities of Parkinson’s disease rats, but also Complete reversal of neuronal peptide Y and dopamine D2 receptor mRNA overexpression caused by denervation in striatum of Parkinson’s disease rats suggests that the neuronal re-dominance of fetal brain substantia nigra transplants may be Is to promote the normalization of gene expression of these two substances the main reason.