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健康成年杂种犬29只,分为失血性休克人参预治疗组(HSG)10只,失血性休克地塞米松预治疗组(HSD)10只,失血性休克组(HS)9只。失血前1小时,HSG组静注人参二醇组皂甙(25mg/kg),HSD组肌注地塞米松(1mg/kg)。在实验过程中经放、输血,使血压维持于5.3kPa(40mmHg)。结果表明,(1)扫描电镜显示,人参二醇组皂甙与地塞米松对血小板形态均有明显保护作用,并抑制其聚集;(2)血清5-HT含量,HS组随失血时间延长逐渐增高。HSG组失血后第1、3小时虽有增高,但第4、5小时则逐渐回降到正常水平,HSD组失血前后均无显著改变。5-HIAA,HS组失血后3～5小时显著增加,HSG和HSD组失血前后比较均无显著改变。提示人参二醇组皂甙和地塞米松对失血性休克时5-HT和5-HIAA的增加有抑制作用。
Twenty-nine healthy adult mongrel dogs were divided into 10 hemorrhagic shock ginseng pretreatment groups (HSG), 10 hemorrhagic shock dexamethasone pretreatment groups (HSD), and 9 hemorrhagic shock groups (HS). One hour before hemorrhage, the HSG group received intravenous infusion of panaxadiol saponin (25 mg/kg), and the HSD group received intramuscular injection of dexamethasone (1 mg/kg). During the experiment, blood was transfused and transfused to maintain the blood pressure at 5.3 kPa (40 mmHg). The results showed that (1) Scanning electron microscopy showed that panaxadiol saponin and dexamethasone both had significant protective effects on platelet morphology and inhibited their aggregation; (2) serum 5-HT levels, HS group gradually increased with prolonged blood loss time . Although the HSG group had increased blood loss at the 1st and 3rd hours, it gradually fell back to the normal level at the 4th and 5th hours. There was no significant change in the HSD group before and after blood loss. In the 5-HIAA and HS groups, blood loss was significantly increased at 3 to 5 hours, and there was no significant change between the HSG and HSD groups before and after blood loss. It is suggested that the panaxadiol saponins and dexamethasone inhibit the increase of 5-HT and 5-HIAA during hemorrhagic shock.