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目的探讨乙肝患者DNA检测与前S1蛋白(preS1)检测的一致性。方法 450例符合乙肝诊断标准的标本,分别对他们进行乙肝五项、preS1及DNA的检测,并进行比较分析。结果前S1抗原阳性245例,阳性率为54.4%,HBV-DNA阳性267例,阳性率为59.3%,差异无统计学意义。各组前S1抗原和DNA阳性检出率经r相关统计学分析,有非常密切的正相关关系。结论 PreS1与HBV-DNA有较好的一致性,可以作为判断HBV在宿主体内活动的指标之一。
Objective To investigate the consistency of DNA testing and preS1 detection in hepatitis B patients. Methods 450 cases of hepatitis B in accordance with the diagnostic criteria of the specimens were tested for hepatitis B, preS1 and DNA, and comparative analysis. Results The positive rate of pre-S1 antigen was 245.4%, HBV-DNA positive was 267, the positive rate was 59.3%, the difference was not statistically significant. The positive rate of pre-S1 antigen and DNA in each group was positively correlated by r-correlation analysis. Conclusion PreS1 has good consistency with HBV-DNA and can be used as one of the indicators to judge HBV activity in the host.