论文部分内容阅读
目的探讨蛛网膜下腔阻滞麻醉联合硬膜外镇痛对子宫肌瘤患者血清糖类抗原125(CA125)、血管内皮生长因子C(VEGF-C)、前列腺素E2(PGE2)水平变化的影响。方法选取2013年6月—2015年2月舞钢公司总医院104例UM患者,按照随机数表法分组,各52例。对照组给予全麻联合自控静脉镇痛,观察组给予蛛网膜下腔阻滞麻醉联合硬膜外镇痛。对比两组手术前及术后48 h血清CA125、VEGF-C、PGE2水平,术后随访1年,统计UM复发率。结果手术前,两组血清CA125、VEGF-C、PGE2水平差异无统计学意义(P>0.05),术后48 h,两组各指标水平均有所降低,且观察组低于对照组,差异有统计学意义(P<0.05);观察组术后复发率为1.92%(1/52),对照组为11.54%(6/52),组间比较差异无统计学意义(P>0.05)。结论蛛网膜下腔阻滞麻醉联合硬膜外镇痛有利于降低UM患者术后血清CA125、VEGF-C、PGE2水平,对预防UM复发具有重要意义。
Objective To investigate the effects of subarachnoid anesthesia combined with epidural analgesia on the changes of serum levels of carbohydrate antigen125 (CA125), vascular endothelial growth factor C (VEGF-C) and prostaglandin E2 (PGE2) in patients with uterine fibroids . Methods From June 2013 to February 2015, 104 cases of UM patients in Wugang General Hospital were divided into two groups according to random number table, each with 52 cases. The control group was given general anesthesia combined with controlled intravenous analgesia. The observation group was given subarachnoid block anesthesia combined with epidural analgesia. The levels of serum CA125, VEGF-C and PGE2 in both groups before and 48 h after operation were compared. One year after the operation, the UM recurrence rate was calculated. Results Before operation, the levels of serum CA125, VEGF-C and PGE2 in the two groups had no significant difference (P> 0.05). At 48 hours after operation, the levels of each index in both groups decreased and the levels in the observation group were lower than those in the control group The recurrence rate was 1.92% (1/52) in the observation group and 11.54% (6/52) in the control group, with no significant difference between the two groups (P> 0.05). Conclusions Subarachnoid anesthesia and epidural analgesia are helpful to reduce the postoperative serum levels of CA125, VEGF-C and PGE2 in patients with UM and are of great significance in preventing the recurrence of UM.