树突状细胞的研究现状及进展

来源 :中国医学文摘(肿瘤学) | 被引量 : 0次 | 上传用户:zhiming0077
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树突状细胞(dendritic cell,DC)是一种重要的免疫辅佐细胞,是体内最有效的专职抗原提呈细胞(APC),具有强大的激活静息T细胞、激发初次免疫应答的独特功能。在肿瘤免疫治疗中具有潜在的应用价值。DC的分化发育过程中存在二个不同的阶段:未成熟的DC,具有摄取、处理抗原的能力;成熟DC,抗原捕获能力丧失,成为激发初次免疫应答的免疫抗原提呈细胞。DC广泛分布于除脑以外的全身各脏器,但其含量很少,外周血淋巴细胞中的比例约为 Dendritic cells (DCs) are important immune adjuvant cells and are the most effective professional antigen-presenting cells (APCs) in the body. They have the unique function of activating resting T cells and stimulating primary immune responses. It has potential value in tumor immunotherapy. There are two different stages in the process of DC differentiation and development: immature DC, which has the ability to ingest and process antigens; mature DCs lose antigen capture ability and become immune antigen-presenting cells that stimulate primary immune responses. DC is widely distributed in the body except the brain of various organs, but its content is very small, the proportion of peripheral blood lymphocytes is about
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