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目的分析氢氯噻嗪治疗辽宁省阜新地区原发性高血压患者的疗效,为低成本控制农村地区高血压提供科学依据。方法随机抽取辽宁省阜新农村地区原发性高血压患者4 511例,给予氢氯噻嗪25 mg,口服1次/d,1个月后测量血压,评价氢氯噻嗪的降压疗效。结果①1个月后得到有效病例4 278例(有效率94.8%),原发性高血压患者治疗后血压平均下降15.8/6.1 mm Hg(P<0.05);②治疗后24.9%的患者血压得到控制,其中男性和女性患者血压控制率分别为21.9%、27.5%(P<0.05)。③不同年龄段35~44岁、45~54岁、55~64岁、≥65岁患者血压控制率分别为28.0%、28.8%、22.1%、22.3%(P<0.05)。④随着血压级别的升高,患者血压控制率逐步下降(36.2%、24.6%、11.2%,P<0.05)。⑤单纯性收缩期高血压患者(738例)血压控制率为35.6%。结论氢氯噻嗪治疗农村地区原发性高血压疗效好,可作为群体降压治疗的一线用药。
Objective To analyze the curative effect of hydrochlorothiazide in patients with essential hypertension in Fuxin area of Liaoning province and to provide a scientific basis for controlling hypertension in rural areas with low cost. Methods A total of 4 511 patients with essential hypertension in rural Fuxin of Liaoning Province were randomized. Hydrochlorothiazide 25 mg was given orally once daily for 1 month. Blood pressure was measured after 1 month. The antihypertensive effect of hydrochlorothiazide was evaluated. Results ① After 1 month, 4 278 effective cases (effective rate 94.8%) were obtained. The blood pressure of patients with essential hypertension decreased 15.8 / 6.1 mm Hg after treatment (P <0.05); ② After the treatment, blood pressure was controlled in 24.9% of the patients Among them, the blood pressure control rates in male and female patients were 21.9% and 27.5%, respectively (P <0.05). ③ The control rates of blood pressure of 35-44 years old, 45-54 years old, 55-64 years old, 65 years old or older in different age groups were 28.0%, 28.8%, 22.1% and 22.3% respectively (P <0.05). ④ With the increase of blood pressure level, the rate of blood pressure control decreased gradually (36.2%, 24.6%, 11.2%, P <0.05). ⑤ Simple systolic hypertension (738 cases) blood pressure control rate was 35.6%. Conclusions Hydrochlorothiazide is effective in treating primary hypertension in rural areas and can be used as first-line therapy for antihypertensive treatment in population.