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目的:探讨合理运用纳络酮治疗急性酒精中毒的方法。方法:67例急性酒精中毒的病人分为纳络酮常规应用组、序贯应用组,分别观察两组病人的清醒时间、清醒后遗症状、心率和SGPT的变化。结果:(1)轻度中毒的病人,常规组的清醒时间为40.1±23.7分,序贯组的清醒时间为18.3±9.4分。重度中毒的病人清醒时间常规组为111.6±57.2分,序贯组为39.7±28.8分。(2)常规组与序贯组的后遗症状分别为:口干72.4%vs5.2%(P<0.01);胃脘部不适65.5%vs7.9%(P<0.01);头痛93.1%vs2.6%(P<0.01);心率增快31.0%vs0。(3)SGPT异常:常规组的SCPT异常率由31%降至24.1%,序贯组的SGPT异常率由28.9%降至2.6%。结论:纳络酮的序贯应用可以缩短急性酒精中毒病人的清醒时间,减轻病人的后遗症状和SGPT异常率,是治疗急性酒精中毒更为合理的方法。
Objective: To explore the rational use of naloxone treatment of acute alcoholism. Methods: Sixty-seven patients with acute alcoholism were divided into routine naloxone application group and sequential application group. The awake time, conscious sequelae, heart rate and SGPT of the two groups were observed. Results: (1) In patients with mild poisoning, the awake time was 40.1 ± 23.7 in the routine group and 18.3 ± 9.4 in the sequential group. Severe poisoning patients wake up routine group was 111.6 ± 57.2 points, sequential group was 39.7 ± 28.8 points. (2) The symptoms of sequelae in the conventional group and the sequential group were: 72.4% vs 5.2% (P <0.01); the discomfort in the stomach was 65.5% vs 7.9% (P <0.01); the headache was 93.1% vs2. 6% (P <0.01); heart rate increased 31.0% vs0. (3) SGPT abnormalities: The rate of abnormal SCPT in the conventional group decreased from 31% to 24.1%, and that of the sequential group decreased from 28.9% to 2.6%. Conclusion: The sequential application of naloxone can shorten the waking time of patients with acute alcoholism and reduce the symptoms and SGPT abnormalities in patients. It is a more reasonable method to treat acute alcoholism.