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目的探究奥曲肽联合红花黄色素治疗重症胰腺炎(SAP)对患者血生化指标的影响。方法 61例重症胰腺炎患者为研究对象,随机分为研究组(31例)与对照组(30例)。两组患者给予相同基础治疗,此外研究组患者采用奥曲肽联合红花黄色素治疗,对照组患者单独采用奥曲肽治疗,观察两组患者各症状改善、胃肠减压时间及治疗后血生化指标水平等。结果研究组患者腹痛缓解时间为(1.60±0.22)d、胃肠减压时间为(6.13±2.07)d、腹胀缓解时间为(2.20±0.21)d,对照组患者腹痛缓解时间为(4.36±0.81)d、胃肠减压时间为(10.55±3.34)d、腹胀缓解时间为(3.75±1.31)d,研究组患者腹痛缓解时间、胃肠减压时间、腹胀缓解时间均显著短于对照组,差异具有统计学意义(P<0.05)。治疗后,研究组患者白介素-6、C反应蛋白水平及白细胞计数均显著低于对照组,差异具有统计学意义(P<0.05)。结论奥曲肽联合红花黄色素治疗重症胰腺炎较单独使用奥曲肽治疗对血生化指标的改善有更好的效果,可推广应用。
Objective To investigate the effect of octreotide combined with safflor yellow on patients with severe pancreatitis (SAP) on blood biochemical markers. Methods Sixty-one patients with severe acute pancreatitis were randomly divided into study group (n = 31) and control group (n = 30). In addition, patients in the study group were treated with octreotide combined with safflower yellow, while those in the control group were treated with octreotide alone. The improvement of symptoms, the time of gastrointestinal decompression and the level of blood biochemical indexes after treatment were observed in both groups . Results The relief time of abdominal pain was (1.60 ± 0.22) d, the duration of gastrointestinal decompression was (6.13 ± 2.07) d and the duration of abdominal distension was (2.20 ± 0.21) d in the study group, and was 4.36 ± 0.81 ) d, gastrointestinal decompression time was (10.55 ± 3.34) d, abdominal distension time was (3.75 ± 1.31) d, the study group patients with abdominal pain relief time, gastrointestinal decompression time, abdominal distension time were significantly shorter than the control group, The difference was statistically significant (P <0.05). After treatment, the levels of interleukin-6, C-reactive protein and leukocyte count in study group were significantly lower than those in control group (P <0.05). Conclusion octreotide combined with safflower yellow pigment treatment of severe pancreatitis than octreotide alone treatment of blood biochemical indicators have better results, can be extended and applied.