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目的分析血浆D-二聚体水平与高血压脑出血病情变化的相关性。方法选择高血压脑出血患者98例作为观察组,同期我院健康体检者98例作为对照组,比较观察组发病后24 h、3 d、4 d、7 d、14 d的血浆D-二聚体水平,并比较不同病情患者间的血浆D-二聚体水平及其异常率。结果观察组发病24 h血浆D-二聚体水平升高较明显(P<0.05),至发病第3天血浆D-二聚体达最高水平,发病第4、7、14天血浆D-二聚体水平逐渐下降;GCS评分越低,出血量越大,破入脑室者及预后不佳者,其血浆D-二聚体水平越高(P<0.05)。结论血浆D-二聚体水平可早期反映高血压性脑出血病情程度,动态监测其水平变化对病情进展、治疗效果及评估预后具有重要价值。
Objective To analyze the correlation between the plasma D-dimer level and the changes of hypertensive intracerebral hemorrhage. Methods Ninety-eight patients with hypertensive intracerebral hemorrhage were selected as the observation group and 98 healthy subjects were selected as the control group during the same period. The levels of plasma D-dimer in the observation group at 24 h, 3 d, 4 d, 7 d and 14 d after the onset of symptoms were compared. The level of plasma D-dimer and its abnormal rate in patients with different diseases were compared. Results The level of plasma D-dimer in observation group increased significantly at 24 h (P <0.05), and the highest level of plasma D-dimer reached on the third day after onset. The plasma D- The level of plasma D-dimer was lower (P <0.05). The lower the GCS score was, the greater the amount of bleeding was. The higher the plasma D-dimer level was (P <0.05). Conclusion Plasma D-dimer level can reflect the severity of hypertensive intracerebral hemorrhage at early stage. The dynamic monitoring of the level of D-dimer is of great value to the progression of the disease, the therapeutic effect and prognosis.