目的 探讨大剂量维生素B_6加硝基安定或托吡酯治疗West综合征的疗效。方法 大剂量维生素B_6(20～30mg·kg~(-1)·d~(-1)静注10～14d后,改口服300～600mg/d)同时加用抗癫癇药硝基安定或托吡酯治疗West综合征。结果 大剂量维生素B_6加硝基安定或托吡酯治疗West综合征效果较好,硝基安定组总有效率为52.6％,托吡酯组总有效率为41.2％,经统计学处理,两组无显著性差异(P>0.05)。结论 治疗West综合征使用维生素B_6加抗癫癇药有肯定疗效,两组均未使用激素治疗,避免了激素对婴幼儿生长发育的不良影响。 Objective To investigate the efficacy of high-dose vitamin B_6 plus nitrazepam or topiramate in the treatment of West syndrome. Methods High dose of vitamin B_6 (20 ~ 30mg · kg -1 · d -1) intravenously 10 ~ 14d after oral administration of 300 ~ 600mg / d) plus antiepileptic drug nitrozepam or topiramate treatment West syndrome. Results High dose of vitamin B_6 plus nitrazepam or topiramate treatment of West syndrome better effect, the total effective rate of the nitrazepam was 52.6%, the total effective rate of topiramate was 41.2%, by statistical analysis, there was no significant difference between the two groups (P> 0.05). Conclusion The treatment of West syndrome with vitamin B_6 plus antiepileptic drugs have a positive effect, no hormonal treatment in both groups, to avoid the hormones on the growth and development of infants and young children adverse effects.