目的目的探究格列吡嗪联合阿卡波糖治疗2型糖尿病的临床疗效。方法选择60例老年2型糖尿病患者,随机分为两组,对照组予以二甲双胍片治疗,观察组予以格列吡嗪联合阿卡波糖治疗,观察对比两组血糖、胰岛β细胞功能变化。结果观察组治疗后的血糖水平、糖化血红蛋白及胰岛β细胞功能指数改善程度均优于对照组,P<0.05。结论对老年2型糖尿病患者予以格列吡嗪联合阿卡波糖治疗,有助于提高控制血糖效果,并改善胰岛β细胞功能。 Objective To investigate the clinical efficacy of glipizide combined with acarbose in the treatment of type 2 diabetes mellitus. Methods Sixty elderly patients with type 2 diabetes mellitus were selected and randomly divided into two groups. The patients in the control group were treated with metformin tablets. The patients in the observation group were treated with glipizide and acarbose. The changes of blood glucose and pancreatic β-cell function were observed and compared. Results After treatment, the improvement of blood glucose, glycosylated hemoglobin and pancreatic β-cell function index in observation group were better than those in control group (P <0.05). Conclusion The elderly patients with type 2 diabetes were treated with glipizide combined with acarbose, help to improve the control of blood glucose and improve pancreatic β-cell function.