一、老化色素脂褐质脂褐质为见于老人脑神经细胞内黄褐色色素颗粒,也见于其他脏器,现已明了这是老化普遍伴有的蓄积增加的物质。其可估测老化的程度,但了解脂褐质生成过程及影响细胞或组织功能、生化和病理生理的途径尚未定论。脂褐质组成成分除含有丙酰基甘油磷脂质、肌固醇丰富的脂质及多种蛋白质外,还含有多量的铁离于。从这种色素颗粒中可用氯仿、甲醇等有机溶剂提取,而且脂质过氧化生成具有共轭的希夫(Schiff)硷及类似荧光特性的物质。机体细胞膜磷脂分子中含有大 First, the aging pigment Lipofuscin Lipofuscin is seen in the elderly brain cells within the brown pigment, also found in other organs, it is now clear that this aging is accompanied by the accumulation of increased material. It can estimate the degree of aging, but understanding of the process of lipofuscin production and affecting cell or tissue function, biochemistry and pathophysiology has not been conclusive. In addition to the composition of lipofuscin containing propionyl glycerophospholipids, lipid-rich and rich in a variety of proteins, but also contains a large amount of iron from. From such pigment particles, it can be extracted with an organic solvent such as chloroform and methanol, and the lipid is oxidized to form a substance having a conjugated Schiff base and similar fluorescence characteristics. Body cell membrane phospholipid molecules contain large