近年研究发现胰岛素样生长因子-Ⅱ与肿瘤关系密切,是肿瘤细胞生长的刺激因子,与其Ⅰ型受体、Ⅱ型受体特异性结合,通过一系列信号转导,发挥多种生物学作用,参与肿瘤的发生、发展、转移及新生血管的形成等。本文介绍胰岛至少样生长因子-Ⅱ的结构、功能以及促进肿瘤发生、发展和转移等方面的研究进展。 In recent years, studies have found that insulin-like growth factor-Ⅱ is closely related to the tumor, is a tumor cell growth stimulator, and its type I receptor, type Ⅱ receptor specific binding through a series of signal transduction play a variety of biological effects, Involved in the occurrence of tumor, development, metastasis and the formation of new blood vessels. This article describes the research progress on the structure and function of at least IGF-Ⅱ and the promotion of tumorigenesis, development and metastasis.