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目的探讨碱性成纤维细胞生长因子(bFGF)在急性白血病(AL)中的表达及其临床意义。方法应用酶联免疫法(ELISA)检测AL初治及复发患者化疗前后血清bFGF的水平,并与正常对照组比较。结果47例AL初治患者血清bFGF水平为(60.57±25.62)pg/L,8例复发患者为(72.26±21.44)pg/L,均明显高于正常人对照组的(24.06±5.97)pg/L,差异有统计学意义(P<0.01);11例完全缓解(CR)患者血清bFGF水平(27.33±9.04)pg/L,较CR前明显下降(P<0.01),接近于正常人对照组的水平(P>0.05);急性淋巴细胞白血病(ALL)难治组血清bFGF的水平为(85.20±31.45)pg/L,明显高于非难治组的(60.03±22.97)pg/L,两者差异有统计学意义(P<0.05);但急性髓细胞白血病(AML)难治组血清bFGF水平(63.36±16.62)pg/L与非难治组的(55.02±22.84)pg/L差异无统计学意义(P>0.05)。结论血清bFGF的检测对了解AL的发生、发展及疗效观察和预后判断有一定临床价值。
Objective To investigate the expression of basic fibroblast growth factor (bFGF) in acute leukemia (AL) and its clinical significance. Methods Serum bFGF levels in patients with newly diagnosed and relapsed AL before and after chemotherapy were measured by enzyme-linked immunosorbent assay (ELISA), and compared with the normal control group. Results The serum level of bFGF in 47 AL patients was (60.57 ± 25.62) pg / L and in the 8 patients (72.26 ± 21.44) pg / L, which were significantly higher than those in control group (24.06 ± 5.97) pg / L, the difference was statistically significant (P <0.01). Eleven patients with complete remission (CR) had significantly lower serum levels of bFGF (27.33 ± 9.04) pg / L than those before CR (P <0.01) (P> 0.05). The level of bFGF in serum of patients with acute lymphoblastic leukemia (ALL) was (85.20 ± 31.45) pg / L, which was significantly higher than that of non-refractory group (60.03 ± 22.97) pg / L (P <0.05). However, there was no significant difference in bFGF level between the two groups (63.36 ± 16.62) pg / L and (55.02 ± 22.84) pg / L in non-refractory Acute Myeloid Leukemia Significance (P> 0.05). Conclusion The detection of serum bFGF has some clinical value in understanding the occurrence, development, clinical observation and prognosis of AL.