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乙型肝炎或非乙型肝炎急性期的早期或潜伏期约有15～20%的患者可有血清病样综合征。在肝炎的症状和体征出现之前几天乃至6周可出现暂时性红斑或斑丘疹兼多关节痛,有时伴有荨麻疹。偶有真性关节炎发生,需与类风湿性关节炎相鉴别。这些症状通常为一时性的,仅持续2至7天,而当病人已出现肝炎的症状与体征来就诊时,可能已将这些前驱临床表现忘掉。患者有HBs抗原血症,补体C_3和C_4以及循环性免疫复合物(HBsAg-IgM、IgG)的暂时性抑制。原发性混合型冷凝球蛋白血症是一以紫癜、关节痛或关节炎、软弱无力为特征的三联征,往往伴有肾
Serum pathological syndrome may occur in about 15% to 20% of patients with an early or latent phase of hepatitis B or non-B acute phase. Temporary erythema or rash and joint pain may occur a few days or even six weeks before the onset of symptoms and signs of hepatitis, with urticaria sometimes associated. Occasional real arthritis occurs, the need to differentiate from rheumatoid arthritis. These symptoms are usually temporary, lasting only two to seven days, and may have forgotten the clinical manifestations of these precursors when the patient has had symptoms and signs of hepatitis. Patients have transient inhibition of HBs antigenemia, complement C_3 and C_4, and circulating immune complexes (HBsAg-IgM, IgG). Primary mixed cryoglobulinemia is a triad characterized by purpura, arthralgia or arthritis, weakness, often associated with kidney