论文部分内容阅读
[目的]开发氟胺氰菊酯的工业化合成线路,打破了国外的技术垄断。[方法]以D-缬氨酸为起始原料合成中间体(R)-氟胺氰菊酸,在甲磺酰氯、吡啶、4-二甲氨基吡啶和甲磺酸等为催化剂下与间苯氧基苯甲醛反应合成氟胺氰菊酯。[结果]氟胺氰菊酯纯度达95%以上,纯度达到了日本进口的原药水平,目前已经处于公斤级生产阶段。[结论]该合成路线具有成本低、操作安全、产品纯度高等优点。
[Objective] To develop industrial synthetic routes of fluvalinate and break the monopoly of technology abroad. [Method] The intermediate (R) -fluorouracil and chrysanthemic acid were synthesized starting from D-valine. Under the catalyst of mesyl chloride, pyridine, 4-dimethylaminopyridine and methanesulfonic acid, Synthesis of fluvalinate by oxybenzaldehyde. [Result] The purity of fluvalinate reached above 95%, and the purity reached the level of the original drug imported from Japan. At present, it has been in kilogram production stage. [Conclusion] The synthetic route has the advantages of low cost, safe operation and high product purity.