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目的:观察思密达联合乌司他丁(UTI)给药对急性百草枯(PQ)中毒大鼠血浆肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)的干预作用,探讨其可能的作用机制。方法:将104只SD大鼠随机分为生理盐水对照组(A组)8只、染毒对照组(B组)32只、UTI对照组(C组)32只、思密达联合UTI干预组(D组)32只。染毒后第1、3、5、7天分批处死各组存活大鼠,测定血浆TNF-α、TGF-β1含量。结果:B、C、D组血浆TNF-α、TGF-β1水平于染毒后第1天开始明显升高,与A组比较差异均有统计学意义(P<0.01);染毒后第1、3天,C组TNF-α、TGF-β1水平低于B组,差异有统计学意义(P<0.05);染毒后第1、3、5、7天,D组TNF-α、TGF-β1表达明显低于B组,差异均有统计学意义(P<0.01),且D组TNF-α、TGF-β1水平也低于C组,差异有统计学意义(P<0.05,P<0.01)。结论:思密达联合UTI能够有效降低PQ中毒大鼠TNF-α、TGF-β1水平,减轻PQ对大鼠的损伤作用。
Objective: To observe the effects of sida combined with ulinastatin (UTI) on plasma levels of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in acute paraquat poisoning rats Role, to explore its possible mechanism of action. Methods: Totally 104 SD rats were randomly divided into saline control group (group A) 8, exposure control group (group B) 32, UTI control group (group C) 32, Smecta combined with UTI intervention group (D group) 32 only. Rats were sacrificed on the 1st, 3rd, 5th, 7th day after exposure to death, and the levels of TNF-α and TGF-β1 in plasma were determined. Results: The levels of TNF-α and TGF-β1 in plasma in group B, C and D increased significantly from the first day after exposure to the first day of exposure, with statistical significance (P <0.01) , And the levels of TNF-α and TGF-β1 in group C were lower than those in group B at 3 days (P <0.05). On days 1, 3, 5 and 7, (P <0.01). The levels of TNF-α and TGF-β1 in group D were also lower than those in group C (P <0.05, P < 0.01). Conclusion: Smecta combined with UTI can effectively reduce the levels of TNF-α and TGF-β1 in rats with PQ poisoning and relieve the injury of PQ in rats.