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锑剂是目前治疗日本血吸虫病的主要药物,但对机体有显著的毒性作用。现在主要就这种制剂对于心脏的毒性作用来进行研究。早在1927年 Chopra 曾在动物实验上注意到锑剂对于心脏的毒性作用,但在药理学书籍上关于锑剂对于心脏的毒性作用,很少注意和分析。至于以往临床方面,只强调锑剂对于肝脏功能的影响,亦不很重视它对于心脏的毒性作用。近年来,由于大规模地应用酒石酸锑钾治疗日本血吸虫病,曾发生突然死亡的病
Antimony agent is currently the main drug for the treatment of schistosomiasis japonica, but has a significant toxic effect on the body. Now mainly on the toxic effects of this preparation on the heart to carry out research. As early as 1927, Chopra noticed the toxic effects of antimony agents on the heart in animal experiments, but little attention and analysis was given in the pharmacological books on the toxic effects of antimony agents on the heart. As for the clinical aspects of the past, only emphasize the impact of antimony agents on liver function, nor pay much attention to its toxic effects on the heart. In recent years, sudden death has occurred due to the large-scale application of antimony potassium tartrate in the treatment of schistosomiasis japonica