论文部分内容阅读
水杨酸钠片在生产中最容易发生的问题是粘铳模和不易崩解。为了解决这个问题,很多药厂都是在增加辅料的基础上而得到了解诀,我们药厂也是同样的情况。原来我们生产水杨酸钠的处方,与全国针片剂交流会议技术资料中介绍的处方和操作非常相似,所用的辅料(糊精或糊精与糖粉)达到主药的40%片重,为0.41克或0.42克。笔者在缩小片型节约辅料的前提下,经多次试制,终于取得了比较良好的效果。兹将比试制依据及操作方法叙述如下,以供参考,并希指正。根据多次的试制,和在生产中的观察与体会,可概括如以下几点。
The most troublesome problems in the production of sodium salicylate tablets are sticky molds and poor disintegration. In order to solve this problem, many pharmaceutical companies are getting solutions on the basis of increasing excipients, and the same is true for our pharmaceutical factories. We originally produced sodium salicylate prescription, and the national needle and tablet exchange meeting technical information described in the prescription and operation are very similar, the use of excipients (dextrin or dextrin and powdered sugar) to reach 40% of the main drug weight, 0.41 g or 0.42 g. The author in reducing the type of material saving premise, after many trials, and finally achieved relatively good results. Hereby will compare the trial basis and method of operation described below, for reference, and hope correct. According to several trial production, and observation and experience in production, can be summarized as follows.