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目的 :研究Ki 67在小儿肾母细胞瘤和小儿肾癌中的表达及其意义。方法 :用免疫组织化学的EnVision法对 2 5例肾母细胞瘤和 8例肾腺癌肿瘤组织进行Ki 67免疫标记。结果 :FH型中Ki 67阳性表达率为 2 8% ,UFH型中Ki 67阳性表达率为10 0 %。有转移或浸润的 88%。肾腺癌Ki 67阳性表达率为 12 %。结论 :Ki 67在小儿肾母细胞瘤肾癌中的表达与病理学分型及肿瘤组织浸润和转移存在密切关系。组织学分型越差、有转移和浸润Ki 67阳性表达越高 ,预后越差。Ki 67能较好反映小儿肾母细胞瘤和肾癌增殖状态 ,对临床诊断与进一步化疗与预后判断有一定价值 ,同时可作为常规病理组织学的一种补充。
Objective: To study the expression and significance of Ki 67 in pediatric nephroblastoma and pediatric renal cell carcinoma. Methods: Immunohistochemistry EnVision method of 25 cases of nephroblastoma and 8 cases of renal adenocarcinoma tumor tissue Ki 67 immunostaining. Results: Ki67 positive expression rate was 28% in FH type and 100% in UFH type. There 88% of the transfer or infiltration. The positive rate of Ki 67 in renal adenocarcinoma was 12%. Conclusion: The expression of Ki 67 in pediatric nephroblastic neoplasia is closely related to the pathological type and infiltration and metastasis of tumor tissue. The poorer the histological type, the higher the metastasis and infiltration Ki 67 expression, the poorer the prognosis. Ki 67 can better reflect the status of pediatric nephroblastoma and renal cell carcinoma proliferation, clinical diagnosis and further chemotherapy and prognosis have some value, and can be used as a routine routine histological complement.