在不对称有机合成领域中,外界手性催化和诱导试剂的应用日益广泛;近年来,氨基醇类化 合物作为手性配体应用于许多不对称反应中,并可获得较高的对映体选择性;如不对称还原反 应,e.e.值一般为 65～96％;不对称 1,2加成反应,e.e.值一般在 85～95％之间;但是,对 于不对称烷基化反应选择性比较低,e.e.值一般在 10～50％之间;另外在光降解共轭反应, l,4加成反应,以及Reformasky反应中也能够诱导出较高的e.e.值;因此,制备手性氨基 醇配体具有重要意义。 In the field of asymmetric organic synthesis, chiral catalytic and inducing reagents are widely used outside the world; in recent years, amino alcohols as chiral ligands in many asymmetric reactions, and can obtain higher enantioselectivity If the asymmetric reduction reaction, the ee value is generally 65 to 96%; asymmetric 1,2 addition reaction, the ee value is generally between 85 to 95%; however, for the asymmetric alkylation reaction selectivity is relatively low , and the ee value is generally between 10 and 50%. In addition, higher ee can also be induced in the photodegradation conjugation reaction, the 1,4-addition reaction and the Reformasky reaction. Therefore, the preparation of chiral amino alcohol ligand It is of great significance.