按卟啉母核的不同合成方法,介绍了卟啉衍生物的合成进展。从各种小分子的缩合而合成卟啉的方法包括经典的Alder-Long法、Lindsey法和新颖的[2+2]法、[3+1]法。这些方法能够合成许多结构复杂的卟啉。对卟啉大分子进行β-、meso-位功能团的引入,有卤代、硝化、甲酰化等,并能进一步转化成其它功能团。 According to different synthesis methods of porphyrin mother nucleus, the progress of synthesis of porphyrin derivatives is introduced. Methods for the synthesis of porphyrins from the condensation of various small molecules include the classical Alder-Long method, the Lindsey method and the novel [2 + 2] method, [3 + 1] method. These methods enable the synthesis of many complex porphyrins. Porphyrin macromolecules for β -, meso-bit functional groups introduced, halogenated, nitration, formylation, etc., and can be further transformed into other functional groups.