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目的对磁共振定量分析在类风湿关节炎手腕部骨侵蚀中的应用进行分析与评价,为今后的临床应用提供参考。方法随机抽取在2007年1月～2011年10月这段时间里采用MRI对手腕部进行扫描的临床患者病例108例,在1周之后均进行了实验室检查,将确诊为类风湿关节炎(RA)的患者作为本次研究的研究对象。将所有研究对象按照性别、年龄、病程、类风湿因子、抗环瓜氨酸肽、C反应蛋白、血沉等观察指标进行分组,采用Mann-Whitney方法对各组间骨侵蚀的差异进行分析。结果在本次研究中所接受检查的108名患者中有73例符合RA标准,约占67.59%;对于CRP阳/阴性组、早期/中晚期RA组以及ESR阳/阴性组间的骨侵蚀评分之间存在的差异有统计学意义(P﹤0.05);对于CCP阳/阴性组之间的骨侵蚀评分存在的差异具有明显的统计学意义(P﹤0.05)。结论磁共振定量分析能够对为类风湿关节炎手腕部骨侵蚀的诊断以及预后评估提供有效的依据,能够在今后的临床诊疗工作中对其予以广泛应用。
Objective To analyze and evaluate the application of magnetic resonance quantitative analysis in the treatment of rheumatoid arthritis at the wrist, and provide a reference for future clinical application. Methods A total of 108 clinical cases were scanned by MRI from January 2007 to October 2011. A total of 108 clinical cases were scanned after one week and were diagnosed as rheumatoid arthritis RA) as the research object of this study. All subjects were grouped according to sex, age, duration of disease, rheumatoid factor, anti-cyclic citrullinated peptide, C-reactive protein, erythrocyte sedimentation rate and other indicators. Mann-Whitney method was used to analyze the differences of bone erosion among groups. RESULTS: Of the 108 patients examined in this study, 73 met the criteria for RA, accounting for 67.59%. For the CRP positive / negative group, early / advanced RA group and ESR positive / negative group, the bone erosion score (P <0.05). There was significant difference in the bone erosion score between CCP positive and negative groups (P <0.05). Conclusion Quantitative magnetic resonance imaging can provide an effective basis for the diagnosis and prognosis evaluation of wrist bones in rheumatoid arthritis, and can be widely used in clinical diagnosis and treatment.