胰岛素样生长因子-I(insulin-like growth factor-I,IGF-I)和甲状腺激素都具有促进物质代谢、促进生长发育的作用,两者相互作用,相互调节。IGF-I与自身免疫性甲状腺疾病的发生、发展有密切关系。IGF-I水平可能与甲状腺癌的恶性度有关。甲状腺功能减低症患儿治疗前血清甲状腺激素和IGF-I水平较低,有效治疗后甲状腺激素和IGF-I均升高,IGF-I可作为甲状腺功能减低症患儿疗效判断的一项观察指标。 Both insulin-like growth factor-I (IGF-I) and thyroid hormones promote metabolism and promote growth and development, and they interact with each other and regulate each other. IGF-I and autoimmune thyroid disease occurrence and development are closely related. IGF-I levels may be related to the degree of malignancy of thyroid cancer. Hypothyroidism before treatment in children with low levels of serum thyroid hormone and IGF-I, effective treatment of thyroid hormone and IGF-I were elevated, IGF-I can be used as a therapeutic index of children with hypothyroidism to judge .