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目的:探索磁感应热疗技术联合放疗治疗不宜手术的颈部淋巴结复发的疗效和安全性。方法:2012年2月至2012年7月选取27例不宜手术的颈部淋巴结复发病例,给予2次磁热籽植入和4-8次不等的加热治疗,计划治疗目标温度为48-50℃、维持30min,磁感应治疗后一周内行放射治疗,治疗结束后1-3个月时复查CT,治疗后6月内不予化疗。结果:治疗结束后3个月时,27例患者中CR55.6%,PR37%,NC3.7%,PD3.7%,治疗总有效率为92.6%;25例疼痛缓解,疼痛缓解有效率92.6%。治疗结束后6个月未发现远处转移病例,未发生大出血、放射性食管炎、放射性骨坏死、骨髓抑制、粒子移位脱落等并发症。结论:磁感应热疗联合放疗治疗不宜手术的复发颈部淋巴结安全、有效。
Objective: To explore the efficacy and safety of magnetic induction hyperthermia in combination with radiotherapy for the treatment of unresectable cervical lymph nodes. Methods: From February 2012 to July 2012, 27 cases of unresectable cervical lymph node recurrence were selected. Two heat-magnet seed implantation and 4-8 times heating treatment were given. The planned treatment target temperature was 48-50 ℃, for 30min, magnetic induction within one week after radiotherapy, 1-3 months after the end of the review CT, no treatment within 6 months after chemotherapy. Results: At 3 months after the end of treatment, the CR55.6%, PR37%, NC3.7% and PD3.7% of the 27 patients had a total effective rate of 92.6%. The pain relief was relieved in 25 cases and the pain relief rate was 92.6% %. No distant metastases were found at 6 months after the end of treatment, and no complications such as hemorrhage, radiation esophagitis, osteonecrosis of the bone, bone marrow suppression and shedding of the particles occurred. Conclusion: Magnetic induction hyperthermia combined with radiotherapy is safe and effective in the treatment of recurrent cervical lymph nodes that are not suitable for operation.