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Objective:To analyze the hepatoprotective effect of the Crossandra infundibuliformis.Methods:Hepatotoxicity was induced by carbon tetrachloride. Petroleum ether extract of dried leaves was administrated to mice for7 days. The hepatoprotective effect of petroleum ether extract was evaluated by the assay of liver function biochemical parameters.Results: The result clearly indicates that petroleum ether extract showed significant hepatoprotection when compared with standard Silumarin.Conclusions:The petroleum ether extract of the leaves ofCrossandra infundibuliformispossess significant acute hepatoprotective activity. Thus further investigation on this species would bring a promising drug for liver disorders.