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本文对33例男性酒精性肝病患者(年龄40～79岁,平均51.7岁)与17例作对照的健康男性(年龄23～54岁,平均35.5岁),用放射免疫分析法测定血浆非结合的雌酮(E_1)、雌二醇—17β(E_2)和雌三醇(E_3)的水平和尿中这些雌激素的结合和非结合形式的排泄最。结果如下:肝病患者血浆E_1水平显著增加,平均值为74.2±8.0微微克/毫升;对照组为26.0±1.7微微克/毫升(P<0.001)。血浆E_2平均值分别为29.3±2.2对23.3±2.0微微克/毫升(P<0.05)。血浆E_3平均值则为11.5±1.9对6.5±0.7微微克/毫升(P<0.01)。肝功能明显异常的肝病患者(严重组)血浆中三种雌激素的平均浓度均较对照组明显升高。尿中E_1、E_2和E_3排泄总量肝病患者亦比对照组显著增加(P<0.01)。肝病患者24小时尿中平
In this study, 33 patients with alcoholic liver disease (aged 40-79 years, mean 51.7 years) and 17 healthy controls (age 23-54 years, average 35.5 years) were included in this study. Radioimmunoassay The levels of estrone (E_1), estradiol-17β (E_2) and estriol (E_3) were the most excreted in the urine in the combined and unconjugated form of these estrogens. The results were as follows: Plasma E 1 levels were significantly increased in patients with liver disease with an average of 74.2 ± 8.0 pg / ml; in the control group, 26.0 ± 1.7 pg / ml (P <0.001). Plasma E_2 mean values were 29.3 ± 2.2 vs 23.3 ± 2.0 pg / mL, respectively (P <0.05). The mean plasma E_3 was 11.5 ± 1.9 vs. 6.5 ± 0.7 pg / mL (P <0.01). The average plasma concentrations of three estrogens in patients with liver disease (severe group) with abnormal liver function were significantly higher than those in the control group. Urine E_1, E_2 and E_3 excretion of liver disease patients than in the control group was significantly increased (P <0.01). 24 hours in patients with liver disease urinary level