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引言寄生虫的免疫反应可受到宿主基因型的影响,而且亦可表现出简单和直接的遗传控制。在宿主应答中的种内差别问题曾经有过记载(Wakelin,1978),但只有在最近对这种差别才做过一定程度的分析。采用多种动物进行实验所受的限制之一是缺少在遗传性上具有明确的宿主种株,但对于已经充分建立有纯种、同族和重组血统的小鼠来说已不受此种限制。采用这样的宿主,就有可能利用株间所存在的差别作为基础,不仅可藉以分析差别的遗传学,而且
Introduction Parasite immune responses can be influenced by host genotypes and can also demonstrate simple and direct genetic control. Intra-species differences in host responses have been documented (Wakelin, 1978), but only to some extent have recent analyzes of such differences been made. One of the limitations with experimentation with a variety of animals is the lack of a genetically defined host strain that has not been limited to mice that have been adequately established with purebred, congenic, and recombinant ancestry. With such a host, it is possible to use the differences that exist between strains as a basis not only to analyze the differential genetics, but also