论文部分内容阅读
目的探讨肝硬化患者血清IGF-Ⅰ和IL-6、IL-8水平的变化及临床意义。方法应用放射免疫分析法,对33例肝硬化患者进行血清IL-6、IL-8和IGF-1含量的测定,并与同期收集的32名正常健康人作比较。结果肝硬化患者血清IGF-Ⅰ水平非常显著地低于正常人组(P<0.01),而血清IL-6、IL-8水平非常显著地高于正常人组(P<0.01)。且血清IGF-Ⅰ水平和IL-6、IL-8水平呈显著负相关(r=-0.4025、-0.5236,P<0.01)。结论检测肝硬化患者血清IGF-Ⅰ和IL-6、IL-8水平的变化,对该病的诊断、指导肝硬化的治疗及观察疗效均有重要的临床价值。
Objective To investigate the changes and clinical significance of serum IGF-Ⅰ, IL-6 and IL-8 levels in patients with cirrhosis. Methods The levels of IL-6, IL-8 and IGF-1 in 33 patients with cirrhosis were measured by radioimmunoassay and compared with 32 normal healthy subjects collected in the same period. Results Serum levels of IGF-Ⅰ in patients with cirrhosis were significantly lower than those in normal controls (P <0.01), while the levels of serum IL-6 and IL-8 in patients with cirrhosis were significantly higher than those in normal controls (P <0.01). Serum IGF-Ⅰ level was significantly negatively correlated with IL-6 and IL-8 (r = -0.4025, -0.5236, P <0.01). Conclusion The detection of serum IGF-Ⅰ, IL-6 and IL-8 levels in patients with cirrhosis has important clinical value in the diagnosis of the disease, the treatment of liver cirrhosis and the observation and treatment of the disease.