目的:新型冠状肺炎流行期间,因为口罩的大量使用等原因,导致市面上一次性医用口罩出现短缺,为临时解决此问题,本文尝试以多种常用消毒方法来探讨与研究一次性医用口罩重复利用的可能性.方法:参照YY/T0969-2013《一次性医用口罩标准》,使用常见的消毒方法: 75％ 乙醇表面消毒、干热消毒、紫外线消毒、煮沸消毒后再使用电吹风进行电荷再生并检测细菌滤过率验证消毒方法对口罩效果的影响.结果:使用SPSS26 卡方分析口罩物理性能、单因素方差分析各样本细菌过滤率分别为:外观完好整洁,鼻梁条长度≥ 10±0.3cm“,”Objective: A large number of masks were used during the outbreak of novel coronary pneumonia, resulting in a shortage of single-use medical face masks on the market. In order to temporarily solve this problem, this paper explores and researches the feasibility of the reuse of single-use medical face masks after being disinfected with common disinfection methods. Methods: According to the Single-use Medical Face Mask (YY/T 0969- 2013), common disinfection methods include surface disinfection with 75％ ethanol, dry heat disinfection, disinfection by ultraviolet light and disinfection by boiling followed by charge regeneration using an electric hairdryer. Then the bacterial filtration efficiency (BFE) was detected to verify the influence of these disinfection methods on the effect of masks. Results: The physical properties of each mask were analyzed by SPSS 26 chi-square analysis and the BFE of each sample was analyzed by one-way analysis of variance. The mask appearance was intact and clean, the length of the nose strip was greater than 10 ± 0.3 cm, and the strength of connection points was greater than 10 N; the BFE was 96.96 ± 0.38 in surface disinfection with 75％ ethanol, 99.55± 0.10 in dry heat disinfection, 99.42 ± 0.13 in disinfection by ultraviolet light, 99.51 ± 0.09 in disinfection by boiling, 90.72 ± 1.01 for a used mask, and 99.57 ± 0.82 for an unused mask; the difference was P ≤ 0.05, all of these data were statistically significant. Conclusion: This research showed that these four common disinfection methods had no significant effect on the physical properties and BFE of single-use medical face masks. However, considering the operability among the public, these methods are not recommended for people with low operational ability.