神经胶质瘤是颅内最常见的恶性肿瘤。然而,由于其瘤体本身浸润性生长,外科手术不易将其与周围正常脑组织区分;化疗药物一方面由于血脑屏障难于到达脑组织,另一方面对周围健康组织也产生较大副作用。如果能构建一种能够穿透血脑屏障且具有靶向作用的给药系统,则可以有效地实现药物杀肿瘤效果。转铁蛋白(transferrin,TF)受体是一种普遍表达于正常细胞和肿瘤细胞表面的受体蛋白,在脑胶质瘤细胞表面的表达是正常细胞 Glioma is the most common intracranial malignancy. However, due to the invasive growth of the tumor itself, it is not easy to differentiate it from the surrounding normal brain tissue. Chemotherapy drugs, on the one hand, have difficulty reaching the brain tissue due to the blood-brain barrier and, on the other hand, have a large side effect on the surrounding healthy tissue. If you can build a can penetrate the blood-brain barrier with a targeted drug delivery system, you can effectively achieve the drug to kill the tumor effect. The receptor of transferrin (TF), a receptor protein that is commonly expressed on the surface of normal cells and tumor cells, is expressed on the surface of glioma cells as normal cells