不明原因复发性流产(URSA)是指经过夫妻双方染色体,母体生殖道解剖结构,内分泌水平及男方精液检查等一系列常规检查后仍未发现明确病因的复发性流产患者~([1])。国内外研究表明,约半数的不明原因复发性流产与免疫因素相关,包括自身免疫紊乱和同种免疫紊乱两大类~([2-3])。不明原因复发性流产患者通过对一系列自身抗体的筛查,排除了自身免疫紊乱因素。因此,不明原因复发性流产视乎与同种免疫紊乱相关,而同种免疫紊乱导致流产的主要原因在于 URSA refers to recurrent miscarriage after a series of routine examinations such as the chromosomes of the spouses, the anatomy of the maternal reproductive tract, the endocrine level, and the man’s sperm examination (1). Domestic and foreign studies have shown that about half of unexplained recurrent spontaneous abortion and immune factors, including autoimmune disorders and immune disorders of the two categories ~ ([2-3]). Patients with unexplained recurrent spontaneous abortion through a series of autoantibodies screening, ruled out autoimmune disorders. Therefore, unexplained recurrent miscarriage appears to be related to alloimmune disorders, and alloimmune disorders lead to miscarriage is the main reason