HBeAg和HBsAg均为阳性的母亲所生的婴儿通常需要进行免疫预防以阻止HBV感染,因为乙型肝炎病毒的围产期传播大多发生于这些婴儿中。但是由于HBeAg阴性、HBsAg阳性母亲所生婴儿也可发生急性肝炎或致死性暴发型肝炎,因而对这些婴儿也需进行免疫预防。本文报告2例此类婴儿的有关情况。例1为男婴,足月产,其母为30岁的初产妇,妊娠期正常,分娩顺利。婴儿于出生后2 1/2月时因出现黄疸而住院。该婴儿无旅 Babies born to mothers with positive HBeAg and HBsAg usually require immunoprophylaxis to prevent HBV infection, as the perinatal transmission of Hepatitis B virus occurs mostly in these infants. However, due to HBeAg-negative, infants born to HBsAg-positive mothers may also develop acute hepatitis or fatal fulminant hepatitis, so immunization is also required for these babies. This article reports 2 cases of such infants. Example 1 for the baby boy, full-term, the mother of 30-year-old primiparous, normal pregnancy, childbirth goes well. The baby was hospitalized for jaundice at 21 1/2 months after birth. The baby has no brigade