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研究表明,内毒素休克病人血清肿瘤坏死因子(TNF)水平明显增高。TNF不仅对组织有直接损伤作用,而且可诱导或协同内毒素(LPS)诱导其它炎症因子分泌,放大炎症效应,是引起全身炎症反应综合征(SIRS)最重要的炎性介质。近年国外研究抗TNF单克隆抗体被...
Studies have shown that patients with endotoxin shock serum tumor necrosis factor (TNF) levels were significantly higher. Tumor necrosis factor (TNF) not only directly damages the tissue, but also induces or synergizes with endotoxin (LPS) to induce the secretion of other inflammatory cytokines and enlarges the inflammatory effect. It is the most important inflammatory mediator of systemic inflammatory response syndrome (SIRS). In recent years, foreign research anti-TNF monoclonal antibody was ...