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目的探讨新诊断T2DM与柯萨奇病毒(COX)、巨细胞病毒(CMV)、单纯疱疹病毒(HSV)及EB病毒(EBV)感染的关系,分析T2DM病毒感染患者血清IL-18、干扰素-γ(IFN-γ)及IFN-γ诱导蛋白-10(IP-10)的水平及意义。方法选取新诊断T2DM患者(T2DM组)208例和健康对照(NC组)者240名,检测血清COX、CMV、HSV、EBV IgG抗体阳性率和炎症因子IL-18、IFN-γ及IP-10水平,比较两组病毒抗体阳性率与炎症因子水平的差异,分析T2DM病毒感染与炎症因子的关系。结果 T2DM组COX、CMV抗体阳性率高于NC组(19.23%vs 0.83%,94.71%vs 83.33%,P<0.01),两组HSV和EBV抗体均为阴性。T2DM组IL-18、IFN-γ及IP-10水平均高于NC组[IL-18:(130.30±118.44)vs(41.69±40.39)pg/ml;IFN-γ:(103.93±110.10)vs(34.50±24.89)pg/ml;IP-10:(2215.50±3395.47)vs(234.55±64.40)pg/ml,P<0.05或P<0.01]。T2DM COX感染者IL-18高于无COX感染者[(142.84±150.63)vs(122.04±92.59)pg/ml,P<0.05]。结论 COX感染与新诊断T2DM的发生发展存在一定的相关性,可能与IL-18等的作用有关。
Objective To investigate the relationship between newly diagnosed T2DM and coxsackievirus (COX), cytomegalovirus (CMV), herpes simplex virus (HSV) and Epstein-Barr virus (EBV) infection and to analyze the relationship between the serum levels of IL-18 and IFN- γ (IFN-γ) and IFN-γ-induced protein-10 (IP-10) levels and significance. Methods Two hundred and twenty new cases of T2DM (T2DM group) and 240 healthy controls (NC group) were selected. The positive rates of serum COX, CMV, HSV and EBV IgG and the levels of inflammatory cytokines IL-18, IFN-γ and IP- Level, the difference between the positive rate of the two antibody and the level of inflammatory cytokines was compared, and the relationship between T2DM virus infection and inflammatory factors was analyzed. Results The positive rates of COX and CMV antibodies in T2DM group were higher than those in NC group (19.23% vs 0.83%, 94.71% vs 83.33%, P <0.01). Both HSV and EBV antibodies were negative in both groups. The levels of IL-18, IFN-γ and IP-10 in T2DM group were significantly higher than those in NC group [IL-18: 130.30 ± 118.44 vs 41.69 ± 40.39 pg / 34.50 ± 24.89) pg / ml; IP-10: (2215.50 ± 3395.47) vs (234.55 ± 64.40) pg / ml, P <0.05 or P <0.01]. IL-18 in patients with T2DM COX was significantly higher than those without COX [(142.84 ± 150.63) vs (122.04 ± 92.59) pg / ml, P <0.05]. Conclusion There is a correlation between COX infection and the occurrence and development of newly diagnosed T2DM, which may be related to the role of IL-18 and so on.