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目前临床应用的几乎所有抗抑郁剂,包括一线用药选择性5-HT重摄取抑制剂(selective seroton in reuptake inh ib itors,SSR Is),都存在起效延迟(显著起效需2~4周)和有效率不高(约75%)的问题。研究表明,5-HT1A受体拮抗剂可增强SSR Is的抗抑郁活性并缩短起效时间,这为新型药物的研
Almost all antidepressants currently in clinical use, including selective seroton in reuptake inhbitors (SSR Is), have a delay in onset of action (2 to 4 weeks for significant onset) And less efficient (about 75%). Studies have shown that 5-HT1A receptor antagonist can enhance the antidepressant activity of SSR Is and shorten the onset time, which is a new drug research