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目的探讨抗磷脂抗体(APA)在正常人的分布及其与系统性红斑狼疮(SLE)的关系。方法应用酶联免疫吸附实验(ELISA)检测82例正常人和32例SLE患者血中6种APA。结果正常人IgG型抗心磷脂抗体(aCL)、抗磷脂酰肌醇抗体(aPI)、抗磷脂酸抗体(aPA)、抗磷脂酰乙醇胺抗体(aPE)、抗磷脂酰丝氨酸抗体(aPS)和抗磷脂酰胆碱抗体(aPC)的阳性率分别为6.10%、6.10%、7.32%、7.32%、3.66%和3.66%,IgM型aCL、aPA、aPC、aPS、aPE和aPI的阳性率分别为2.44%、3.66%、3.66%、6.10%、6.10%和4.88%。SLE患者IgG型aCL、aPA、aPS、aPC、aPI的A值和阳性率显著高于正常人,IgM型aCL、aPA、aPS、aPE、aPC的A值和阳性率显著高于正常人;SLE时IgG和IgM型APA的总阳性率分别为68.75%和71.88%。结论在正常人中存在滴度较低的APA;这些APA互相间有一定的关系,多同时出现。SLE时进行APA检查,对抗磷脂综合征的诊断可能有一定的意义。
Objective To investigate the distribution of antiphospholipid antibody (APA) in normal subjects and its relationship with systemic lupus erythematosus (SLE). Methods Six kinds of APA were detected in 82 normal subjects and 32 SLE patients by enzyme linked immunosorbent assay (ELISA). Results Normal human IgG anticardiolipin antibody (aCL), anti-phosphatidylinositol antibody (aPI), anti-phosphatidic acid antibody (aPA), anti-phosphatidyl ethanolamine antibody (aPE), anti-phosphatidylserine antibody The positive rates of phosphatidylcholine antibody (aPC) were 6.10%, 6.10%, 7.32%, 7.32%, 3.66% and 3.66% respectively. The positive rates of aCL, aPA, aPC, aPS, aPE and aPI of IgM were 2.44 %, 3.66%, 3.66%, 6.10%, 6.10% and 4.88%. The A value and positive rate of aCL, aPA, aPS, aPC and aPI of IgG in patients with SLE were significantly higher than those in normal people, and the A value and positive rate of aPC, aPA, aPS, aPE and aPC were significantly higher than those in normal subjects; The total positive rates of IgG and IgM APA were 68.75% and 71.88% respectively. Conclusion There is a low titer of APA in normal people. These APAs have certain relationship with each other and appear more often. APA SLE examination, the diagnosis of phospholipid syndrome may have some significance.