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利用ATR探头和中红外光导纤维红外光谱法在体表测定34个正常甲状腺和20个结节性甲状腺肿 的傅里叶变换红外光谱。并比较了二者之间13条谱带的27个指标的差异。结果表明:结节性甲状腺肿的体 表红外光谱中:(1)-2 925 cm-1谱带(-CH2的反对称伸缩振动)的峰位,-1 250 cm-1(P=O的伸缩振 动)谱带的峰位均明显地向低波数方向移动(P<0．05);(2)谱带的相对强度(谱峰高度)比值H1 740／H1 460, H1 160／H1 460和H1 160／H1 120较正常甲状腺明显降低(P<0．05);(3)H1 080／H1 460比值明显升高(P=0．008)。 这些差异是利用体表红外光谱诊断结节性甲状腺肿的基础。
Fourier Transform Infrared Spectroscopy of 34 Normal Thyroid and 20 Nodular Goiter on the Body Surface Using ATR Probe and Mid-Infrared Fiber Optic Infrared Spectroscopy. The differences of 27 indexes between 13 bands were compared. The results showed that: (1) The peak position of -2 925 cm-1 band (the antisymmetric stretching vibration of -CH2) in the infrared spectrum of nodular goiter, -1 250 cm-1 (P = O (P <0.05); (2) The ratio of the relative intensities of the bands (peak height) H1 740 / H1 460, H1 160 / H1 460 and H1 160 / H1 120 was significantly lower than that of normal thyroid (P <0.05); (3) The ratio of H1 080 / H1 460 was significantly increased (P = 0.008). These differences are the basis for the diagnosis of nodular goiter using body surface infrared spectroscopy.