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目的探讨抗抑郁剂药物辅以针对性心理治疗技术对有儿童受虐史抑郁症的疗效。方法对60例有儿童受虐史的抑郁症患者近似随机地分成心理治疗加药物治疗组和单用药物组,两组各30例,在治疗后1、2、4、6个月,评定两组的HAMD减分率和临床总体印象量表(CGI)中的疗效改善分值,并根据HAMD减分率和CGI的疗效改善分值来比较两组临床疗效。结果单一药物组和药物联合心理治疗组在治疗后1、2、4月时,两组的HAMD减分率及CGI的总体改善分值的差异无统计学意义(P>0.05)。6个月时,药物联合心理治疗技术组的HAMD减分率及CGI的总体改善分值均大于单一药物组,差异具有统计学意义(P<0.05)。结论短期内,心理治疗联合药物治疗组与单纯的药物治疗组相比,并未显示出较好的疗效,但远期效果好于单一的药物治疗。
Objective To investigate the efficacy of antidepressant drugs supplemented with targeted psychotherapy on depression in children with history of depression. Methods A total of 60 depression patients with a history of child abuse were randomly divided into psychological therapy plus drug therapy group and single drug therapy group, 30 cases in each group. At 1, 2, 4 and 6 months after treatment, Group HAMD reduction rate and the clinical total impression scale (CGI) score improvement score, and according to HAMD reduction rate and CGI improvement score to compare the clinical efficacy of both groups. Results There was no significant difference in HAMD reduction rate and CGI overall improvement scores between the two groups at 1, 2 and 4 months after treatment in the single drug group and the drug combination psychotherapy group (P> 0.05). At 6 months, the HAMD reduction rate and CGI overall improvement scores of the combination therapy group were significantly higher than those of the single drug group, with statistical significance (P <0.05). Conclusion In the short term, psychotherapy combined with drug treatment group did not show better efficacy than simple drug treatment group, but the long-term effect was better than single drug treatment.