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本文观察了15只雌性家兔服用复方十八甲后血脂指标的变化(OC 组)。另15只家兔服可溶性淀粉赋形剂作为对照组。实验家兔每四周给药一次,2片/只,于每服药周期的中、末期(即每周期的第2周和第4周)取空腹血测定血清脂质含量变化。连继观察28周,结果发现服用复方十八甲家兔的血清HDL-C、HDL_2-C 水平、HDL_2-C/HDL_3-C 及HDL-C/TCh 比值均明显高于对照组(P<0.05);而TCh、LDL-C 及致动脉粥样硬化指数等值明显低于对照组(P<0.05)。结果提示复方十八甲对家兔脂代谢产生良好影响。
In this paper, we observed the changes of serum lipids in 15 female rabbits (OC group). Another 15 rabbits served soluble starch excipients as control group. The experimental rabbits were dosed once every four weeks, and each group was given fasting blood at the middle and the end of each medication cycle (ie, the second week and the fourth week of each cycle) to measure the change of serum lipid content. After continuous observation for 28 weeks, the HDL-C and HDL-C levels, the HDL-C / HDL-3-C and HDL-C / TCh ratios in the 18 rabbits were significantly higher than those in the control group ), While TCh, LDL-C and atherogenic index were significantly lower than those of the control group (P <0.05). The results suggest that compound 18 A good effect on lipid metabolism in rabbits.