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磺胺类药物的抗菌作用是由于在细菌新陈代谢过程中,抑制了二氢叶酸合成酶,使细菌不能利用对氨基苯甲酸合成二氢叶酸。磺胺增效剂——甲氧苄氨嘧啶[2,4二氨基,5(3,4,5三甲氧基苄基)嘧啶,商品名 Trimethoprim,简称 TMP]也是一种新型广谱抗菌剂,共作用原理则系抑制细菌代谢过程中的二氢叶酸还原酶,使二氢叶酸不能还原为四氢叶酸。TMP 与磺胺药联合应用,能双重阻断细菌的新陈代谢,使细菌不能合
The antibacterial effect of sulfa drugs is due to inhibition of dihydrofolate synthase during bacterial metabolism, so that bacteria can not use p-aminobenzoate to synthesize dihydrofolate. Trimethoprim (Trimethoprim, also known as TMP), a sulfonamide synergist-trimethoprim [2,4 diamino, 5 (3,4,5trimethoxybenzyl) pyrimidine, is also a new broad spectrum antibacterial agent Principle of action is the inhibition of bacterial metabolism of dihydrofolate reductase, dihydrofolate can not be reduced to tetrahydrofolate. TMP and sulfa drugs in combination, can double the bacterial metabolism, so that bacteria can not be combined