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目的:探究微创经皮椎弓根螺钉内固定术对单椎体Magerl A型胸腰椎骨折患者伤椎椎体前缘高度及伤椎Cobb角的影响。方法:回顾本院2015年1月至2017年1月期间收治的单椎体Magerl A型胸腰椎骨折患者71例,其中31例接受微创经皮椎弓根螺钉内固定术治疗的患者作为观察组,40例接受开放椎弓根内固定术治疗的患者作为对照组。患者术后均随访1年,比较两组患者围术期相关指标,手术前、手术后7 d、1年伤椎前缘高度和Cobb角,Oswestry功能障碍评分情况。结果:观察组患者切口长度、下地时间、术中出血量均小于对照组,差异均有统计学意义(n P0.05)。两组患者术前血清CK酶、CRP水平比较差异均无统计学意义(n P>0.05);术后两组患者血清CK酶、CRP水平均明显上升,且观察组患者明显低于对照组,差异均有统计学意义(n P0.05);术后7 d、1年两组患者伤椎前缘高度均明显高于术前(n P0.05);术后7 d、1年两组患者Oswestry功能障碍评分均明显降低,且观察组明显低于对照组,差异均有统计学意义(n P0.05); the levels of serum CK and CRP in the two groups increased significantly after operation, and those in the control group were significantly higher than those in the observation group (n P0.05); 7 days and 1 year after operation, the height of the anterior edge of the two groups was significantly higher than that before operation (n P0.05); the scores of Oswestry dysfunction were significantly reduced in both groups 7 days and 1 year ater operation, and the observation group was significantly lower than the control group (n P<0.01).n Conclusions:Minimally invasive percutaneous pedicle screw fixation can effectively improve the anterior height and Cobb angle of the injured vertebra in patients with single vertebra magerl A thoracolumbar fracture, and the perioperative indexes, serum inflammatory factors and Oswestry dysfunction scores are better than those of open pedicle internal fixation, which is worthy of clinical application.