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目的 了解应用基因工程α干扰素治疗小儿慢性病毒性肝炎的近、远期副作用发生情况。方法 2 6 1例慢性肝炎随机分组 ,用α干扰素治疗 ,以 114例同期治疗的成人病毒性肝炎做对照 ,观察副作用。观察时间平均 5～ 6年 ,最长 10年。结果 近期副作用主要表现为中、低度发热。小儿发热≤ 38℃组比成人少 (χ2 =2 2 .3 ,P <0 .0 0 1) ,流感样症状也少于成人 (χ2 =16 .1,P <0 .0 0 1)。长期观察部分类风湿因子阳性、抗核抗体阳性者 (2 % )未影响治疗。治疗对甲状腺功能 (血清T3 ,T4,TSH)和肾功能 (BUN ,Cr)也无影响。不同的肝病病因 (乙型和丙型 )、病理改变 (≤G2组和≥G3组 )患儿发生副作用无差别。结论 α干扰素治疗小儿病毒性肝炎是安全可行的
Objective To understand the application of genetically engineered interferon alpha in the treatment of children with chronic viral hepatitis in the near and long-term side effects. Methods Twenty-six patients with chronic hepatitis were randomly assigned to treatment with interferon-alpha, and 114 adult patients with concurrent viral hepatitis were treated as controls to observe side effects. Observation of an average of 5 to 6 years, up to 10 years. Results The recent side effects mainly manifested as moderate and low fever. Children with fever less than 38 ℃ than adults (χ2 = 23.2, P <0.001), flu-like symptoms were less than adults (χ2 = 16.1, P <0.001). Long-term observation of some rheumatoid factor positive, anti-nuclear antibody positive (2%) did not affect the treatment. Treatment also had no effect on thyroid function (serum T3, T4, TSH) and renal function (BUN, Cr). Different causes of liver disease (B and C), pathological changes (≤G2 and ≥G3 group) children with no difference in side effects. Conclusions Alpha interferon is safe and feasible for the treatment of pediatric viral hepatitis