前列腺癌(PCa)是欧美国家最常见的恶性肿瘤,病死率居第二位,仅次于肺癌[1],近年来我国前列腺癌的发病率亦有明显增高趋势[2]。其发病机制尚不十分清楚,但许多流行病学研究发现,前列腺癌的发病率具有明显的种族差异,如美国黑人的发病率为中国汉族人的60倍[3],因此从遗传角度研究 Prostate cancer (PCa) is the most common malignancy in Europe and the United States, with the second highest mortality rate after lung cancer [1]. In recent years, the incidence of prostate cancer in China has also been significantly increased [2]. Its pathogenesis is not yet clear, but many epidemiological studies have found that the incidence of prostate cancer has obvious racial differences, such as the incidence of African Americans is 60 times the Chinese Han [3], so from a genetic point of view