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目的探讨危重病患者早期肾功能损害的敏感指标。方法回顾性分析我科2007年1月至2007年6月所收住的152例病人。结果在152例病人中,胱蛋白酶抑制剂C异常者有78例,阳性率为51.32%(78/152),出现异常的时间为(15±6)h;内生肌酐清除率异常者有53例,阳性率为34.87%(53/152),出现异常的时间为(59±6)h;血肌酐异常者有31例,阳性率为20.39%(31/152),出现异常的时间为(98±6)h。结论胱蛋白酶抑制剂C作为肾小球滤过功能早期损害的敏感指标,能够及时、准确地反映出早期肾功能损害。危重病患者应常规监测胱蛋白酶抑制剂C,对病人的肾功能损害做出早期判断。
Objective To explore the sensitive index of early renal dysfunction in critically ill patients. Methods A retrospective analysis of our department from January 2007 to June 2007 received 152 patients. Results Among the 152 patients, 78 cases were abnormal cystatin C, the positive rate was 51.32% (78/152) and the abnormal time was (15 ± 6) h. The abnormalities of endogenous creatinine clearance rate were 53 For example, the positive rate was 34.87% (53/152) and the abnormal time was (59 ± 6) h. There were 31 cases with abnormal serum creatinine and the positive rate was 20.39% (31/152). The abnormal time was ( 98 ± 6) h. Conclusions Cystatin C, as a sensitive indicator of early damage of glomerular filtration function, can reflect the early renal dysfunction timely and accurately. Critically ill patients should be routinely monitored for cystatin C, making early judgments of the patient’s renal impairment.