根据国内外文献报道,多种动物(马、猪、牛、羊、鼠等)体内抗戊型肝炎病毒(HEV)抗体阳性,提示HEV是人兽共患病。为进一步探明HEV的动物宿主、传播方式及致病机制,本文对实验感染HEV动物模型的研究进展进行了综述。 According to the domestic and foreign literature, a variety of animals (horses, pigs, cattle, sheep, mice, etc.) in vivo anti-hepatitis E virus (HEV) antibody positive, suggesting that HEV is zoonosis. In order to further explore the animal host, the mode of transmission and the pathogenic mechanism of HEV, the research progress of experimental HEV animal model was reviewed in this paper.